Title of article
A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells
Author/Authors
Kyung Noo Kim، نويسنده , , Jiyong Lee، نويسنده , , Dong Hoon Kim، نويسنده , , Jong-Shin Yoo، نويسنده , , Ho Jeong Kwon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
77
To page
79
Abstract
Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC50 of 15 μM.
Keywords
Antitumor activity , Thymidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795153
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