Title of article
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core
Author/Authors
Gary T. Wang، نويسنده , , Sheldon Wang، نويسنده , , Robert Gentles، نويسنده , , Thomas Sowin، نويسنده , , Clarence J. Maring، نويسنده , , Dale J. Kempf، نويسنده , , Warren M. Kati، نويسنده , , Vincent Stoll، نويسنده , , Kent D. Stewart، نويسنده , , W. Graeme Laver، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
125
To page
128
Abstract
(±)-(2R,3R,5R)-[2-(1′-S-Acetamido-3′-methyl)butyl-3-methoxycarbonyl]tetrahydrofuran-5-carboxylic acid (9) and (±)-(2R,3R,5R)-[2-(1′-S-acetamido-3′-methyl)butyl-3-(4′-imidazolyl)]tetrahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC50 of about 0.5 μM and NA B with an IC50 of 1.0 μM.
Keywords
Neuraminidase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795163
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