Title of article
Tubulin-polymerization inhibitors derived from thalidomide
Author/Authors
Shunsuke Inatsuki، نويسنده , , Tomomi Noguchi، نويسنده , , Hiroyuki Miyachi، نويسنده , , Sawako Oda، نويسنده , , Toyotaka Iguchi، نويسنده , , Masahiro Kizaki، نويسنده , , Yuichi Hashimoto، نويسنده , , Hisayoshi Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
321
To page
325
Abstract
2-(2,6-Diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione (5HPP-33), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent tubulin-polymerization-inhibiting activity, comparable to that of the known tubulin-polymerization inhibitors, rhizoxin and colchicine. A major metabolite of thalidomide, 5-hydroxythalidomide, which possesses a hydroxyl group at the position corresponding to that of 5HPP-33, also showed moderate inhibitory activity.
Keywords
thalidomide , Tubulin , polymerization , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795200
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