Author/Authors :
Teruaki Hasegawa، نويسنده , , Tomohisa Fujisawa، نويسنده , , Shuichi Haraguchi، نويسنده , , Munenori Numata، نويسنده , , Ryouji Karinaga، نويسنده , , Taro Kimura، نويسنده , , Shiro Okumura، نويسنده , , Kazuo Sakurai، نويسنده , , Seiji Shinkai، نويسنده ,
Abstract :
Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.
Keywords :
schizophyllan , Antisense delivery system , cancer , folic acid
