Title of article
Schizophyllan–folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier
Author/Authors
Teruaki Hasegawa، نويسنده , , Tomohisa Fujisawa، نويسنده , , Shuichi Haraguchi، نويسنده , , Munenori Numata، نويسنده , , Ryouji Karinaga، نويسنده , , Taro Kimura، نويسنده , , Shiro Okumura، نويسنده , , Kazuo Sakurai، نويسنده , , Seiji Shinkai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
327
To page
330
Abstract
Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO4-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.
Keywords
schizophyllan , Antisense delivery system , cancer , folic acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795201
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