Title of article
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors
Author/Authors
Tae-Sook Jeong، نويسنده , , Kyung Soon Kim، نويسنده , , Hana Yu، نويسنده , , Mi-Jeong Kim، نويسنده , , Kyung-Hyun Cho، نويسنده , , Yang-Kyu Choi، نويسنده , , Hyoung-Chin Kim، نويسنده , , Ho-Yong Park، نويسنده , , Woo Song Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
385
To page
388
Abstract
A series of 2a–i were prepared from a lead compound, saucerneol B (1) for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a–g exhibited the high specificity of hACAT-1 than hACAT-2, whereas 2h and 2i showed very weak inhibitory activities in both hACAT-1 and hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
Keywords
ACAT inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795212
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