Title of article
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B
Author/Authors
Song Feng، نويسنده , , Yu Xia، نويسنده , , Dongmei Han، نويسنده , , Chunyan Zheng، نويسنده , , Xuchang He، نويسنده , , Xican Tang، نويسنده , , Donglu Bai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
523
To page
526
Abstract
By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB.
Keywords
AChE inhibitors , Huperzine B , derivatives , Bis-HupB
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795235
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