Title of article
Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS
Author/Authors
Nicola Paesano، نويسنده , , Stefania Marzocco، نويسنده , , Caterina Vicidomini، نويسنده , , Carmela Saturnino، نويسنده , , Giuseppina Autore، نويسنده , , Giovanni De Martino، نويسنده , , Gianluca Sbardella، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
539
To page
543
Abstract
Novel benzyl- and phenyl-isothioureidic derivatives have been synthesised and evaluated as inhibitors of nitric oxide synthesis, induced in lipopolysaccharide (LPS)-activated J774.A1 macrophage cell line. The most potent iNOS inhibitor resulting was 1-methyl-3-phenyl-S-methyl isothiourea 5l.
Keywords
Isothioureas , iNOS , nitric oxide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795239
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