Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities

A remarkable increase in antimalarial in vitro activity was achieved by integration of spiroadamantane motifs in 6-alkylidene 1,2,4-trioxanes 3a–h via diastereoselective photooxygenation of allylic alcohols and subsequent BF3-catalyzed peroxyacetalization with adamantanone to give the active compounds 3e–h.