Title of article
A new bactericidal lead structure for the protection of materials
Author/Authors
Erasmus Vogl، نويسنده , , Rainer Bruns، نويسنده , , Oliver Kretschik، نويسنده , , Hermann Uhr، نويسنده , , Johannes Kaulen، نويسنده , , Martin Kugler، نويسنده , , Peter Wachtler، نويسنده , , Wolfgang Kreiss، نويسنده , , Günther Eberz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
625
To page
629
Abstract
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
Keywords
Biocide , Lead structure
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795256
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