Author/Authors :
Erasmus Vogl، نويسنده , , Rainer Bruns، نويسنده , , Oliver Kretschik، نويسنده , , Hermann Uhr، نويسنده , , Johannes Kaulen، نويسنده , , Martin Kugler، نويسنده , , Peter Wachtler، نويسنده , , Wolfgang Kreiss، نويسنده , , Günther Eberz، نويسنده ,
Abstract :
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
