Title of article
Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides
Author/Authors
Hisatsugu Yamada، نويسنده , , Kazuhito Tanabe، نويسنده , , Sei-ichi Nishimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
665
To page
668
Abstract
Photosensitized one-electron oxidation of 5-methylcytosine in DNA by 2-methyl-1,4-naphthoquinone, attached to 5′-end of an oligodeoxynucleotide strand, produced 5-formylcytosine and led to selective DNA strand cleavage at the original 5-methylcytosine configuration. This specified photoreaction is useful for positive display of 5-methylcytosine in DNA on a sequencing gel.
Keywords
4-naphthoquinone , Photosensitized oxidation , 2-methyl-1 , 5-Methylcytosine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795263
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