Title of article
Active site directed inhibitors of replication-specific bacterial DNA polymerases
Author/Authors
George E. Wright، نويسنده , , Neal C. Brown، نويسنده , , Wei-Chu Xu، نويسنده , , Zheng-yu Long، نويسنده , , Chengxin Zhi، نويسنده , , Joseph J. Gambino، نويسنده , , Marjorie H. Barnes، نويسنده , , Michelle M. Butler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
729
To page
732
Abstract
7-Substituted-N2-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram− bacteria.
Keywords
DNA polymerase , Replication , Competitive inhibitors , Antibacterial , Broad spectrum
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795276
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