Author/Authors :
George E. Wright، نويسنده , , Neal C. Brown، نويسنده , , Wei-Chu Xu، نويسنده , , Zheng-yu Long، نويسنده , , Chengxin Zhi، نويسنده , , Joseph J. Gambino، نويسنده , , Marjorie H. Barnes، نويسنده , , Michelle M. Butler، نويسنده ,
Abstract :
7-Substituted-N2-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram− bacteria.
Keywords :
DNA polymerase , Replication , Competitive inhibitors , Antibacterial , Broad spectrum
