Title of article
7-Substituted-N2-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram− bacteria.
Author/Authors
Jian-kang Jiang، نويسنده , , Craig J. Thomas، نويسنده , , Susanne Neumann، نويسنده , , Xinping Lu، نويسنده , , Kenner C. Rice، نويسنده , , Marvin C. Gershengorn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
733
To page
736
Abstract
We report the synthesis of and binding to the two subtypes of mouse thyrotropin-releasing hormone (TRH) receptors, TRH-R1 and TRH-R2, of several 1-(phenyl)isoquinoline carboxamide analogues. These analogues showed a degree of selectivity for binding at TRH-R2. These are the first ligands reported that show selective binding to these receptors.
Keywords
TRH , PK 11195 , TRH receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795277
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