Title of article
DNA topoisomerase I inhibitors from Rinorea anguifera
Author/Authors
Hong-Ji Ma and Rui Nie، نويسنده , , Shannon H. Jones، نويسنده , , Rebekah Marshall، نويسنده , , Xihan Wu، نويسنده , , Sidney M. Hecht and Stewart Shuman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
813
To page
816
Abstract
An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I–DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795293
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