Author/Authors :
Deborah A. Evrard، نويسنده , , Ping Zhou، نويسنده , , Soo Y. Yi، نويسنده , , Dahui Zhou، نويسنده , , Deborah L. Smith، نويسنده , , Kelly M. Sullivan، نويسنده , , Geoffrey A. Hornby، نويسنده , , Lee E. Schechter، نويسنده , , Terrance H. Andree، نويسنده , , Richard E. Mewshaw، نويسنده ,
Abstract :
Derivatives of the serotonin reuptake inhibitor 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine, in which serotonin 1A (5-HT1A) receptor pharmacophoric elements are incorporated, are reported. Analogs exhibiting affinity for both the serotonin transporter and the 5-HT1A receptor are described. Compounds containing 1-(4-indolyl)piperazine and 2-(1H-indol-4-yloxy)ethylamine are promising leads for further SAR studies.
Keywords :
Serotonin , SSRI , 5-HT1A receptor antagonist , Antidepressant
