Title of article :
Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I
Author/Authors :
Daisuke Kamiya، نويسنده , , Yuki Uchihata، نويسنده , , Eiko Ichikawa، نويسنده , , Kuniki Kato، نويسنده , , Kazuo Umezawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Suppression of resistance to anticancer drugs by COTC of glyoxalase I (GloI) inhibitor targeting intracellular glutathione (GSH) and GloI was studied. Depletion of the cellular GSH content and inhibition of GloI by COTC increased chemotherapy-mediated apoptosis in apoptosis-resistant pancreatic adenocarcinoma AsPC-1 cells.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
