Author/Authors :
Silvia Fonquerna، نويسنده , , Montse Miralpeix، نويسنده , , Llu?s Pagès، نويسنده , , Carles Puig، نويسنده , , Arantxa Card?s، نويسنده , , Francisca Ant?n، نويسنده , , Dolors Vilella، نويسنده , , M?nica Aparici، نويسنده , , José Prieto، نويسنده , , Graham Warrellow، نويسنده , , Jorge Beleta، نويسنده , , Hamish Ryder، نويسنده ,
Abstract :
The synthesis and structure–activity relationships of piperidinylpyrrolopyridines as potent and selective H1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the duration of action in vivo and lack of sedative properties.
