Title of article :
Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Author/Authors :
Céline Bonnefous، نويسنده , , Jean-Michel Vernier، نويسنده , , John H. Hutchinson، نويسنده , , Janice Chung، نويسنده , , Grace Reyes-Manalo، نويسنده , , Theodore Kamenecka، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists.
Keywords :
mGluR5 , Amides , CNS disorders
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
