Title of article :
Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors
Author/Authors :
Jason Z. Vlahakis، نويسنده , , Robert T. Kinobe، نويسنده , , Raymond J. Bowers، نويسنده , , James F. Brien، نويسنده , , Kanji Nakatsu، نويسنده , , Walter A. Szarek، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). A number of these compounds, which are structurally distinct from metalloporphyrin HO inhibitors, were found to be selective for the HO-1 isozyme (stress induced), and had substantially less inhibitory activity on HO-2, the constitutive isozyme.
Keywords :
Selective inhibitors , Heme , carbon monoxide , Azalanstat , Heme oxygenase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
