Author/Authors :
Tae-Sook Jeong، نويسنده , , Mi-Jeong Kim، نويسنده , , Hana Yu، نويسنده , , Kyung Soon Kim، نويسنده , , Joong-Kwon Choi، نويسنده , , Sung-Soo Kim، نويسنده , , Woo Song Lee، نويسنده ,
Abstract :
A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a–n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a–c showed the most potent in vitro inhibitory activity on human Lp-PLA2.
