Title of article :
Synthesis of isonicotinic acid N′-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents
Author/Authors :
Neelima Sinha، نويسنده , , Sanjay Jain، نويسنده , , Ajay Tilekar، نويسنده , , Ram Shankar Upadhayaya، نويسنده , , Nawal Kishore Dubey، نويسنده , , Gour Hari Jana، نويسنده , , Sudershan K. Arora، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A new series of antituberculosis agents 6–9 was designed, synthesized and evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv and clinical isolates in an agar dilution method. Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H37Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis.
Keywords :
synthesis , Tuberculosis , Antituberculosis activity , 2-Oxo-2-(4-aryl-piperazin-1-yl)-ethyl-substituent , Isonicotinic acid hydrazide derivatives
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
