Author/Authors :
David R. Anderson، نويسنده , , Shridhar Hegde، نويسنده , , Emily Reinhard، نويسنده , , Leslie Gomez، نويسنده , , William F. Vernier، نويسنده , , National Chiao Tung University
Chung Len Lee، نويسنده , , Shuang Liu، نويسنده , , Aruna Sambandam، نويسنده , , Patricia A. Snider، نويسنده , , Liaqat Masih، نويسنده ,
Abstract :
A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported.
