Author/Authors :
William D. Schmitz، نويسنده , , Derek J. Denhart، نويسنده , , Allison B. Brenner، نويسنده , , Jonathan L. Ditta، نويسنده , , Ronald J. Mattson، نويسنده , , Gail K. Mattson، نويسنده , , Thaddeus F. Molski، نويسنده , , John E. Macor، نويسنده ,
Abstract :
A series of N,N-dimethylhomotryptamines was prepared and their binding affinities at the serotonin transporter (SERT) were determined. Compounds possessing an electron withdrawing substituent at the C5-position of the indole nucleus were found to be potent SSRIs. Initial attempts at conformational restriction of the propylamine sidechain by incorporation of a quinuclidine bicyclic structure did not improve binding affinity at SERT.
