Title of article :
Combinatorial approaches towards the discovery of new tryptase inhibitors
Author/Authors :
Montserrat del Fresno، نويسنده , , Dolors Fern?ndez-Forner، نويسنده , , Montserrat Miralpeix، نويسنده , , Victor Segarra، نويسنده , , Hamish Ryder، نويسنده , , Miriam Royo and Maria J. Macias، نويسنده , , Fernando Albericio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The synthesis and evaluation as tryptase inhibitors of a library of 2,5-diketopiperazine derivatives containing guanidine or amidine functional groups is reported. Among the compounds evaluated, derivatives 6{CG4-CG8} and 6{CG4-CG9} are the most active compounds and have marked selectivity towards tryptase in front of trypsine.
Keywords :
combinatorial chemistry , solid-phase , Diketopiperazine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
