Title of article :
Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors
Author/Authors :
Guy Falardeau، نويسنده , , Hugo Lachance، نويسنده , , Annie St-Pierre، نويسنده , , Constantin G. Yannopoulos، نويسنده , , Marc Drouin، نويسنده , , Jean Bédard، نويسنده , , Laval Chan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.
Keywords :
hCMV , Polycyclic heterocyclic compounds , Anti-virals , Macrocycle , Anti-proliferative agents , HSV , Naphthyridine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
