Title of article
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis
Author/Authors
Sylvie D. Barchéchath، نويسنده , , Rommel I. Tawatao، نويسنده , , Maripat Corr، نويسنده , , Dennis A. Carson، نويسنده , , Howard B. Cottam، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1785
To page
1788
Abstract
The synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl]quinolinium bromide (11) showed a potent protective effect with an EC50 of 0.013 μM, which was at least 300-fold more potent than the reference compound pifithrin-α.
Keywords
Apoptosis , dexamethasone , Thymocyte
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795477
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