Title of article
Novel and potent cyclic cyanamide-based cathepsin K inhibitors
Author/Authors
David N. Deaton، نويسنده , , Anne M. Hassell، نويسنده , , Robert B. McFadyen، نويسنده , , Aaron B. Miller، نويسنده , , Larry R. Miller، نويسنده , , Lisa M. Shewchuk، نويسنده , , Francis X. Tavares، نويسنده , , Derril H. Willard Jr.، نويسنده , , Lois L. Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1815
To page
1819
Abstract
Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
Keywords
Cathepsin K , Cyanamide , Cysteine protease inhibitor , Warhead
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795484
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