Title of article
1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors
Author/Authors
Dmitri V. Kravchenko، نويسنده , , Vladimir V. Kysil، نويسنده , , Alexey P. Ilyn، نويسنده , , Sergey E. Tkachenko، نويسنده , , Sergey Maliarchouk، نويسنده , , Ilya M. Okun، نويسنده , , Alexandre V. Ivachtchenko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1841
To page
1845
Abstract
Synthesis, biological evaluation and structure–activity relationships for a series of novel nonpeptide small molecule inhibitors of caspase-3 are described. Among the studied compounds, 8-sulfamide derivatives of 1,3-dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines have been identified as potent inhibitors of caspases-3. The most active compound within this series (8f) inhibited caspase-3 with IC50 = 4 nM.
Keywords
caspase-3 , 4-c]quinoline , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795489
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