Title of article :
Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles
Author/Authors :
Afshin Zarghi، نويسنده , , Sayyed A. Tabatabai، نويسنده , , Mehrdad Faizi، نويسنده , , Avideh Ahadian، نويسنده , , Parisa Navabi، نويسنده , , Vahideh Zanganeh، نويسنده , , Abbas Shafiee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.
Keywords :
3 , 4-oxadiazoles , anticonvulsant , Substituted 1 , Benzodiazepine receptor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
