Title of article
Antimalarial activity of 2,4,6-trisubstituted pyrimidines
Author/Authors
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
1881
To page
1883
Abstract
A series of 2,4,6-trisubstituted pyrimidines (3a–o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5–2 μg/mL. These compounds are in vitro several folds more active than pyrimethamine.
Keywords
dihydrofolate reductase , Antimalarial , Pyrimidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795497
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