Title of article
Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors
Author/Authors
Sharad Verma، نويسنده , , Dhanapalan Nagarathnam، نويسنده , , Jianxing Shao، نويسنده , , Lei Zhang، نويسنده , , Jin Zhao، نويسنده , , Yamin Wang، نويسنده , , Tindy Li، نويسنده , , Eric Mull، نويسنده , , Istvan Enyedy، نويسنده , , Chunguang Wang، نويسنده , , Qingming Zhu، نويسنده , , Martha Altieri، نويسنده , , Jerold Jordan، نويسنده , , Thu-Thi-Anh Dang، نويسنده , , Sanjeeva Reddy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
1973
To page
1977
Abstract
A series of aminobenzimidazole-substituted pyrimidines were synthesized and evaluated for biochemical activity against CDK1. A high-speed parallel synthesis approach enabled the identification of a potent lead series having improved potency in the CDK1 assay (IC50 < 10 nM). Cell cycle analysis showed that the compounds induced a G2/M block. Docking studies were carried out with a CDK1 homology model, and provide a rationale for the observed activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795513
Link To Document