Title of article :
Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles
Author/Authors :
Alireza Foroumadi، نويسنده , , Shirin Pournourmohammadi، نويسنده , , Fatemeh Soltani، نويسنده , , Mitra Asgharian-Rezaee، نويسنده , , Shahriar Dabiri، نويسنده , , Arsalan Kharazmi، نويسنده , , Abbas Shafiee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a–d and 6a–j) were synthesized and evaluated against Leishmania major promastigotes using 3H-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC50 = 0.1 μM).
Keywords :
1 , 3 , 4-thiadiazole , Nitrofuran , Nitrothiophene , Leishmanicidal activity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
