Title of article :
Binding of isotryptamines and indenes at h5-HT6 serotonin receptors
Author/Authors :
Renata Kolanos، نويسنده , , Uma Siripurapu، نويسنده , , Manik Pullagurla، نويسنده , , Mohamed Riaz، نويسنده , , Vince Setola، نويسنده , , Bryan L. Roth، نويسنده , , Malgorzata Dukat، نويسنده , , Richard A. Glennon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
To determine if the indolic nitrogen atom is required for the binding of N1-benzyltryptamines at h5-HT6 serotonin receptors, several isotryptamines and indene analogs were examined. The affinity of 3-benzyl-N1-(N,N-dimethylaminoethyl)indole (5, Ki = 32 nM) and 1-benzyl-3-(N,N-dimethylaminoethyl)indene (11, Ki = 3 nM) indicates that the indolic nitrogen atom is not essential for binding.
Keywords :
5-HT6 , Serotonergic ligands , Binding requirements
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
