Title of article :
Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02
Author/Authors :
Yoshinosuke Usuki، نويسنده , , Koichi Mitomo، نويسنده , , Noriko Adachi، نويسنده , , Xu Ping، نويسنده , , Ken-Ichi Fujita، نويسنده , , Osamu Sakanaka، نويسنده , , Katsuharu Iinuma، نويسنده , , Hideo Iio، نويسنده , , Makoto Taniguchi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure–activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.
Keywords :
Respiratory inhibition , UK-2A , Nine-membered dilactone , structure–activity relationship , antifungal activity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
