Title of article
Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02
Author/Authors
Yoshinosuke Usuki، نويسنده , , Koichi Mitomo، نويسنده , , Noriko Adachi، نويسنده , , Xu Ping، نويسنده , , Ken-Ichi Fujita، نويسنده , , Osamu Sakanaka، نويسنده , , Katsuharu Iinuma، نويسنده , , Hideo Iio، نويسنده , , Makoto Taniguchi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2011
To page
2014
Abstract
Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure–activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.
Keywords
Respiratory inhibition , UK-2A , Nine-membered dilactone , structure–activity relationship , antifungal activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795521
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