Title of article
N-DEVD-N′-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay
Author/Authors
Zhiqiang Wang، نويسنده , , Jinfang Liao، نويسنده , , Zhenjun Diwu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2335
To page
2338
Abstract
A novel caspase-3 substrate N-Ac-DEVD-N′-MC-R110, which is a fluorogenic substrate cleavable in a single step, has been prepared. It has a significantly higher enzyme turnover rate and sensitivity for detecting caspase-3 activity both in solution and living cells than existing fluorogenic substrates.
Keywords
HTS , Fluorescent , Fluorogenic substrates , caspase , Apoptosis , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795584
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