Title of article
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid
Author/Authors
Jeffrey A. Pfefferkorn، نويسنده , , Meredith L. Greene، نويسنده , , Richard A. Nugent، نويسنده , , Rebecca J. Gross، نويسنده , , Mark A. Mitchell، نويسنده , , Barry C. Finzel، نويسنده , , Melissa S. Harris، نويسنده , , Peter A. Wells، نويسنده , , John A. Shelly، نويسنده , , Robert A. Anstadt، نويسنده , , Robert E. Kilkuskie، نويسنده , , Laurice A. Kopta، نويسنده , , Francis J. Schwende، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
2481
To page
2486
Abstract
A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.
Keywords
HCV Polymerase , inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795611
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