Title of article
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors
Author/Authors
Jinyou Xu، نويسنده , , Lan Wei، نويسنده , , Robert Mathvink، نويسنده , , Jiafang He، نويسنده , , You-Jung Park، نويسنده , , Huaibing He، نويسنده , , Barbara Leiting، نويسنده , , Kathryn A. Lyons، نويسنده , , Frank Marsilio، نويسنده , , Reshma A. Patel، نويسنده , , Joseph K. Wu، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2533
To page
2536
Abstract
anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. These are among the most potent compounds reported to date lacking an electrophilic trap. The most potent compound among these is 5-oxo-1,2,4-oxadiazole 44, which is a 3 nM DPP-IV inhibitor.
Keywords
DPP-IV
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795621
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