Author/Authors :
Jinyou Xu، نويسنده , , Lan Wei، نويسنده , , Robert Mathvink، نويسنده , , Jiafang He، نويسنده , , You-Jung Park، نويسنده , , Huaibing He، نويسنده , , Barbara Leiting، نويسنده , , Kathryn A. Lyons، نويسنده , , Frank Marsilio، نويسنده , , Reshma A. Patel، نويسنده , , Joseph K. Wu، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده ,
Abstract :
anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. These are among the most potent compounds reported to date lacking an electrophilic trap. The most potent compound among these is 5-oxo-1,2,4-oxadiazole 44, which is a 3 nM DPP-IV inhibitor.
