Author/Authors :
Ashok V. Purandare، نويسنده , , Aiming Gao، نويسنده , , Honghe Wan، نويسنده , , John Somerville، نويسنده , , Christine Burke، نويسنده , , Carrie Seachord، نويسنده , , Wayne Vaccaro، نويسنده , , John Wityak، نويسنده , , Michael A. Poss، نويسنده ,
Abstract :
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
