Title of article :
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives
Author/Authors :
Guangxin Xia، نويسنده , , Jianfeng Li، نويسنده , , Aiming Peng، نويسنده , , Shunan Lai، نويسنده , , Shujun Zhang، نويسنده , , Jingshan Shen، نويسنده , , Zhonghua Liu، نويسنده , , Xinjian Chen، نويسنده , , RuYun Ji، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin-4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compounds exhibit improved selectivity versus PDE1 and PDE6. Meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro.
Keywords :
2-e]purin-4(3H)-one , Sildenafil , PDE5 inhibitor , Erectile dysfunction
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
