Title of article
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives
Author/Authors
Guangxin Xia، نويسنده , , Jianfeng Li، نويسنده , , Aiming Peng، نويسنده , , Shunan Lai، نويسنده , , Shujun Zhang، نويسنده , , Jingshan Shen، نويسنده , , Zhonghua Liu، نويسنده , , Xinjian Chen، نويسنده , , RuYun Ji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2790
To page
2794
Abstract
Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin-4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compounds exhibit improved selectivity versus PDE1 and PDE6. Meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro.
Keywords
2-e]purin-4(3H)-one , Sildenafil , PDE5 inhibitor , Erectile dysfunction
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795672
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