Title of article :
Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates
Author/Authors :
Pei-Pei Kung، نويسنده , , Luke R. Zehnder، نويسنده , , Jerry J. Meng، نويسنده , , Stanley W. Kupchinsky، نويسنده , , Donald J. Skalitzky، نويسنده , , M. Catherine Johnson، نويسنده , , Karen A. Maegley، نويسنده , , Anne Ekker، نويسنده , , Leslie A. Kuhn، نويسنده , , Peter W. Rose، نويسنده , , Laura A. Bloom، نويسنده ,
Abstract :
The structure-based design, chemical synthesis, and biological evaluation of novel MTAP substrates are described. These compounds incorporate various C5′-moieties and are shown to have different kcat/Km values compared with the natural MTAP substrate (MTA).
