Title of article
Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking
Author/Authors
Rachel C. LePla، نويسنده , , Cyrille A.S. Landreau، نويسنده , , Michael Shipman، نويسنده , , John A. Hartley، نويسنده , , George D.D. Jones، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2861
To page
2864
Abstract
A series of bisepoxides based on the epoxide domain of the naturally occurring azinomycins have been synthesised. The incorporation of an aminomethyl group into the linker between the two alkylating epoxide units is shown to significantly enhance in vitro cytotoxicity against human tumour cell lines and DNA interstand cross-linking efficiency.
Keywords
epoxides , Anti-cancer , DNA alkylation , Interstrand cross-linking
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795686
Link To Document