Title of article
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)
Author/Authors
Stefan Tasler، نويسنده , , Jürgen Kraus، نويسنده , , Stefano Pegoraro، نويسنده , , Andrea Aschenbrenner، نويسنده , , Elena Poggesi، نويسنده , , Rodolfo Testa، نويسنده , , Gianni Motta، نويسنده , , Amedeo Leonardi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
2876
To page
2880
Abstract
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan® technology, a new lead series was identified and further structurally investigated. Ki’s as low as around 100 nM were achieved.
Keywords
metabotropic glutamate receptor , Molecular modeling , non-competitive antagonist , Neuroplasticity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795689
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