Title of article
Synthesis and structure–activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists
Author/Authors
Stefania Storelli، نويسنده , , Pauline Verdijk، نويسنده , , Dennis Verzijl، نويسنده , , Henk Timmerman، نويسنده , , Andrea C. van de Stolpe، نويسنده , , Cornelis P. Tensen، نويسنده , , Martine J. Smit، نويسنده , , Iwan J.P. De Esch، نويسنده , , Rob Leurs، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
2910
To page
2913
Abstract
A series of 3-phenyl-3H-quinazolin-4-ones have been synthesized and tested for affinity and activity at the chemokine CXCR3 receptor. The most potent compound (1d) has been evaluated using radioligand binding and calcium mobilization assays and is considered a useful tool for further characterization of the CXCR3 receptor.
Keywords
Chemokine , CXCR3 , synthesis , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795697
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