Title of article
Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator
Author/Authors
Jun-Feng He، نويسنده , , Liuhong Yun، نويسنده , , Rifang Yang، نويسنده , , Zhi-Yong Xiao، نويسنده , , Jun-Ping Cheng، نويسنده , , Wen-Xia Zhou، نويسنده , , Yong-Xiang Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
2980
To page
2985
Abstract
A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-α production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo.
Keywords
Immunomodulator , Quinoline-3-carboxamide , Linomide , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795709
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