Title of article
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives
Author/Authors
Prasad P. Dixit، نويسنده , , Prathap S. Nair، نويسنده , , Vijaykumar J. Patil، نويسنده , , Sanjay Jain، نويسنده , , Sudershan K. Arora، نويسنده , , Neelima Sinha، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3002
To page
3005
Abstract
A series of novel (un)substituted benzotriazolyl oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 20, 21, 24, 29 and 30 from this series were found to be equipotent or more potent than linezolid in vitro.
Keywords
benzotriazole , Oxazolidinone , Linezolid , resistant bacteria
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795714
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