Title of article
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists
Author/Authors
Pauline C. Ting، نويسنده , , Shelby P. Umland، نويسنده , , Robert Aslanian، نويسنده , , Jianhua Cao، نويسنده , , Charles G. Garlisi، نويسنده , , Ying Huang، نويسنده , , James Jakway، نويسنده , , Zhidan Liu، نويسنده , , Himanshu Shah، نويسنده , , Fang Tian، نويسنده , , Yuntao Wan، نويسنده , , Neng-Yang Shih، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3020
To page
3023
Abstract
Structure–activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure–activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795718
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