Title of article
Antimalarial activity and synthesis of new trisubstituted pyrimidines
Author/Authors
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
3130
To page
3132
Abstract
A series of 2,4,6-trisubstituted-pyrimidines was synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Out of the 30 compounds synthesized 21 compounds showed MIC in the range of 0.5–2 μg/mL. These compounds are in vitro several folds more active than pyrimethamine.
Keywords
Antimalarial , dihydrofolate reductase , Pyrimidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795740
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