Title of article
Synthesis of carbamate-linked lipids for gene delivery
Author/Authors
Dongliang Liu، نويسنده , , Jianjun Hu، نويسنده , , Weihong Qiao، نويسنده , , Zongshi Li، نويسنده , , Shubiao Zhang، نويسنده , , Lvbo Cheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3147
To page
3150
Abstract
Series of lipids 1a–d and 2a,b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome-mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure–function relationship of how these factors affect cationic lipids on gene delivery performance.
Keywords
Gene delivery , Structure–function relationship , Carbamate-linked , lipids
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795744
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