Title of article
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
Author/Authors
B.A. Bhat، نويسنده , , K.L. Dhar، نويسنده , , S.C. Puri، نويسنده , , A.K. Saxena، نويسنده , , M. Shanmugavel، نويسنده , , G.N. Qazi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3177
To page
3180
Abstract
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
Keywords
Chalcone analogues , cell lines , In vitro cytotoxicity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795750
Link To Document