Author/Authors :
Anna Ramunno، نويسنده , , Malgorzata Dukat، نويسنده , , Mase Lee، نويسنده , , Richard Young، نويسنده , , Mohamed El-Zahabi، نويسنده , , M. Imad Damaj، نويسنده , , Billy Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Abstract :
6-(2-Phenylethyl)nicotine (1b; Ki = 15 nM) was unexpectedly found to bind at α4β2 nicotinic cholinergic (nACh) receptors. Although this compound failed to produce nicotine-like agonist action in several functional assays, 1b antagonized the antinociceptive effects of nicotine (mouse tail-flick assay) in a dose-dependent fashion when administered via an intrathecal route.
