Title of article
Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro
Author/Authors
Yuli Xie، نويسنده , , Huasheng Ding، نويسنده , , Lihui Qian، نويسنده , , Xueming Yan، نويسنده , , Chunhao Yang، نويسنده , , Yuyuan Xie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
3267
To page
3270
Abstract
In an effort to generate novel anti-osteoporosis agents, new bisphosphonates with various benzoyl groups on side chains have been synthesized and evaluated for activities on both bone resorption and bone formation in vitro. Several candidates showed distinct dual activities: promoting bone formation and inhibiting bone resorption.
Keywords
bisphosphonates , osteoporosis , Osteoblast , Osteoclast
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795769
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